Clinical and diagnostic aspects of mixed cryoglobulinemia in patients with chronic viral hepatitis C

Objective: to study the frequency and clinical manifestations of cryoglobulinemia in a population patients with chronic hepatitis C at different stages fibrosis. Materials methods: The source is 23492 HCV who are registered dispensary according Register Chelyabinsk region. studied was randomly formed - 100 verified HCV. As part ongoing single-stage study, standard general biochemical studies (bilirubin, ALT, AST, GGT), RNA blood subsequent genotyping virus, qualitative quantitative analysis for serum cryoglobulins (cryocrite level), instrumental methods research (ultrasound, transient liver elastometry determination degree fibrosis on METAVIR scale) were performed each patient. Results: Cryoglobulins found 63 (63%). At same time, stage 4 14 (22%), 3 8 (13%), 2 1 (1.5%), grade 1-17 (27%), 0-23 (36.5%). Of total number patients, only 22 (35%) had complaints cryoglobulinemia. In vast majority cases, hemorrhagic purpura recorded 18 (28.5%), volatile arthralgia (6.5%). Clinical mixed observed 35% (hemorrhagic purpura, arthralgia). A reliable correlation obtained between level cryocrit female sex pair coefficient 0.237 (p<0.05). Conclusion: data indicate need constant monitoring HCV, early etiotropic therapy direct antiviral drugs